Abstract The hydrodistillated essential oil from fruits of Guarea macrophylla Vahl ssp. tuberculata (Meliaceae) was analyzed by capillary GC and GC/MS. Twenty-four sesquiterpenes were identified, representing 92.9% of volatiles, among which 78.2% were hydrocarbons and 14.7% were oxygenated components. The major components were found to be Î±-copaene (10.3%), viridiflorene (14.6%) and cadina-1,4-diene (17.5%).