The essential oils of two samples of Ophryosporus piquerioides (D.C.) Benth. ex Baker growing wild in Bolivia were analyzed to determine their chemical composition. These samples were collected at two different periods of the year and although the same components appear in both samples, the relative percentages show an important variation. Davanone and its isomer isodavanone, (E)-nerolidol and caryophyllene oxide are the main components in both samples A and B: 65 and 30%, respectively. Camphor, borneol, and bornyl acetate are important minor components: 8.0 and 14.2%, respectively. Camphene (2.0 and 2.4%) and Î²-caryophyllene (3.3 and 6.1%) are the main hydrocarbon compounds. However, the four davana ethers are observed in sample A: almost 7%. Only traces of these compounds are observed in sample B. Finally, 6Î±-hydroxygermacra-1(10),4-diene and Î²-davanon-2-ol are noticeable products in sample B (3.1 and 1.9%).