The hydrodistilled leaf essential oil of Inula cuspidata (Wall. ex DC) C.B. Clarke was investigated using capillary gas chromatographyâflame ionization detector (GCâFID) and GCâmass spectrometry (GCâMS). A total of fifty-two constituents, representing 83.4% of the total oil composition were identified. The oil was mainly dominated by sesquiterpenoids (78.1%) with small amounts of monoterpenoids (3.0%) and benzenoid components (2.7%). The major constituents of the essential oil were presilphiperfolan-8-ol (17.4%), ar-curcumene (17.0%), (E)-Î²-farnesene (8.2%), isoledene (6.7%), presilphiperfol-7-ene (5.5%), (E)-caryophyllene (4.1%), silphiperfol-6-ene (3.8%), silphinene (3.0%), cameroonal-7-Î±-ol (2.6%), Î±-pinene (1.8%) and silphiperfol-5-ene (1.5%). Characteristic of the I. cuspidata leaf oil was the presence of rare tricyclic sesquiterpenoids in larger amounts. To the best of our knowledge, at least forty-five constituents were identified for the first time in I. cuspidata leaf essential oil.