Abstract The essential oil isolated by hydrodistillation from the aerial parts of Salvia angulata H.B.K., (Lamiaceae) collected from southwestern Venezuela, was analyzed by GC and GC/MS. Among the 22 identified compounds, the major components were the sesquiterpenes hydrocarbons which made up 79.8% of the oil, with Î²-caryophyllene (27.7%), germacrene D (19.5%) and bicyclogermacrene (18.3%) as the most abundant ones. Oxygenated sesquiterpenes made up 14.2% of the oil, while the monoterpene fraction was only 3.3%. As far as we know, this is the first report on S. angulata essential oil.