Essential oils and solvent extracts of E. brevifolia F.M and E. strickalndii M. were screened for their chemical composition, and biological activities. 39 compounds were identified in, E. brevifolia F. M. EOs, whereas 41 volatile compounds were identified in E. stricklandii M. EOs. The organic extracts were rich on polyphenols and tannins. The IC50 of the ME of E. stricklandii M. using DPPH· assay was 4.4 ± 0.2 µg/mL. Concerning AChE, the aqueous extract of E. brevifolia F.M. exhibited the highest IC50 value 10.0 ± 0.0 µg/mL. Regarding the anti-inflammatory capacity, E. brevifolia F.M. EOs and E. stricklandii M. ME showed the best IC50 (7.3 µg/mL and 9.7 µg/mL) against the inhibition of 15-LOX. Both plants exhibited a good activity against gram-negative bacteria. Finally, E. stricklandii M. ME was the best cytotoxic extract against HCT116 and K562 with IC50s of 18.0 ± 0.1 µg/mL and 1.8 ± 0.0 µg/mL.