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Title cytotoxic activity and antioxidant effects oforiganum onitesessential oil and its two major contents, carvacrol andp-cymene on human colorectal (hct116) and hepatocelluler carcinoma (hepg2) cell lines
Journal journal of essential oil research
Year 2022
DOI 10.1080/10412905.2022.2107101
Cited By 21
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Abstract
origanum onites l. (o. onites) is one of the cultivated origanum species in turkey. the aim of this study was to determine the cytotoxicity and cellular antioxidant effects of o. onites essential oil, carvacrol and p-cymene on hct116 and hepg2 cells. o. onites essential oil components were analyzed by gc/ms and gc/fid. cytotoxicity was analyzed via the mtt assay in hct116 and hepg2 cells. cellular antioxidant activities of o. onites essential oil, carvacrol and p-cymene were determined with dcfh-da method. gc/ms analysis identified carvacrol (%78.4) as the main constituent of o. onites essential oil. 400 ug/ml concentration of o. onites essential oil, carvacrol and p-cymene were found to be active against hct116 and hepg2 cells. also, carvacrol showed higher cellular antioxidant activity than o. onites essential oil and p-cymene. we conclude that o. onites essential oil and carvacrol may be a candidate for pharmaceutical products in treatment of cancer.
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Plants
32
Compounds
32
Records

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Compounds
Plants
Plant Parts
All Records
CompoundCount
carvone1
1-octen-3-ol1
alpha-terpinene1
alpha-thujene1
alpha-phellandrene1
alpha-pinene1
alpha-terpineol1
aromadendrene1
beta-bisabolene1
beta-caryophyllene1
beta-phellandrene1
beta-terpinene1
borneol1
camphene1
carvacrol1
carvacryl acetate1
trans-sabinene hydrate1
caryophyllene oxide1
cis-sabinene hydrate1
delta-cadinene1
gamma-cadinene1
gamma-terpinene1
limonene1
linalool1
linalyl acetate1
myrcene1
para-cymene1
spathulenol1
t-cadinol1
terpinen-4-ol1
terpinolene1
thymol1
PlantFamily
Origanum oniteslamiaceae
Plant PartCount
aerial parts32
PlantCompoundPart%
Origanum onites 1-octen-3-ol aerial parts 0.1
Origanum onites alpha-phellandrene aerial parts 0.2
Origanum onites alpha-pinene aerial parts 0.4
Origanum onites alpha-terpinene aerial parts 1.3
Origanum onites alpha-terpineol aerial parts 0.2
Origanum onites alpha-thujene aerial parts 1.1
Origanum onites aromadendrene aerial parts 0.1
Origanum onites beta-bisabolene aerial parts 1.1
Origanum onites beta-caryophyllene aerial parts 0.5
Origanum onites beta-phellandrene aerial parts 0.2
Origanum onites beta-terpinene aerial parts 0.1
Origanum onites borneol aerial parts 0.4
Origanum onites camphene aerial parts 0.3
Origanum onites carvacrol aerial parts 78.4
Origanum onites carvacryl acetate aerial parts 0.1
Origanum onites carvone aerial parts 0.05
Origanum onites caryophyllene oxide aerial parts 0.1
Origanum onites cis-sabinene hydrate aerial parts 0.2
Origanum onites delta-cadinene aerial parts 0.05
Origanum onites gamma-cadinene aerial parts 0.1
Origanum onites gamma-terpinene aerial parts 6.9
Origanum onites limonene aerial parts 0.2
Origanum onites linalool aerial parts 1.4
Origanum onites linalyl acetate aerial parts 0.1
Origanum onites myrcene aerial parts 0.6
Origanum onites para-cymene aerial parts 4.1
Origanum onites spathulenol aerial parts 0.1
Origanum onites t-cadinol aerial parts 0.2
Origanum onites terpinen-4-ol aerial parts 0.7
Origanum onites terpinolene aerial parts 0.1
Origanum onites thymol aerial parts 0.2
Origanum onites trans-sabinene hydrate aerial parts 0.4