abstractsalvia aytachii vural & adig"uzel species belong to the lamiaceae family. it is an endemic plant and is locally known as 'ay salbasi'. salvia species are generally known as adacayi in anatolia. it has a wide variety of traditional uses concerning the digestive system. in this study, cross-sections were taken from the leaves and stem to determine the anatomical features of s. aytachii. the characteristic elements were determined with the help of a microscope. chemical components of the essential oil were determined by gas chromatography-flame ionization detector (gc-fid) and gas chromatography-mass spectrometry (gc-ms) systems. a total of 79 compounds corresponding to 91.1% of s. aytachii essential oil were determined. major compounds were identified as camphor (20.3%), 1,8-cineole (20.0%), camphene (6.0%), myrcene (5.6%), valeranone (5.5%,) borneol (5.0%) and -pinene (4.3%). to evaluate in vitro antimicrobial activity of the essential oil, broth microdilution method was used against staphylococcus aureus atcc 6538, escherichia coli nrrl b-3008, bacillus cereus nrrl b-3711, bacillus subtilis nrrl b-4378 and candida albicans atcc 90,028. the results were found to be significant in terms of antimicrobial efficacy.keywords: salvia aytachiianatomyessential oilgc/msantimicrobial activity disclosure statementno potential conflict of interest was reported by the author(s).