the anticancer and anti-inflammatory activities of wild-sage (lantana camara) leaves essential oil were evaluated against various human cell lines. in this regard, steam hydro-distillation technique was used for oil extraction. chemical characterization of l. camara essential oil (lceo) was done by gc-ms, and forty one chemical components (98.69%) were detected in leaves of lceo. the major constituents were caryophyllene oxide (19.63%), caryophyllene (6.68%), -phellandrene (6.48%), humulene epoxide ii (5.68%), spathulenol (4.17%), -pinene (3.27%), eucalyptol (3.09%), -cyclocitral (2.89%), -pinene (2.38%), and nerolidol ii (2.33%). moreover, the antioxidant and antimicrobial potential of lceo were also examined. lceo also showed good anti-inflammatory activity. interestingly, it was found that the l. camara essential oil was active against a set of microbial strains along with promising antioxidant activity. the mtt assay showed that lceo possessed good anticancer potential against u-266, a-549, hct-116, scc-4, miapaca 2, and kbm-5 cancer cell lines. in these cell lines, it was depicted that the lceo blocked the tumor cell proliferation via nf-b pathway suppression. the promising and potent bioactivities of lceo support the candidature of these essential oils as an anticancer agent.