syzygium cumini (pomposia) is a well-known aromatic plant belonging to the family myrtaceae, and has been reported for its various traditional and pharmacological potentials, such as its antioxidant, antimicrobial, anti-inflammatory, and antidiarrheal properties. the chemical composition of the leaf essential oil via gas chromatography-mass spectrometry (gc/ms) analysis revealed the identification of fifty-three compounds representing about 91.22% of the total oil. the identified oil was predominated by -pinene (21.09%), followed by -(e)-ocimene (11.80%), d-limonene (8.08%), -pinene (7.33%), and -terpineol (5.38%). the tested oil revealed a moderate cytotoxic effect against human liver cancer cells (hepg2) with an ic50 value of 38.15 +/- 2.09 ug/ml. in addition, it effectively inhibited acetylcholinesterase with an ic50 value of 32.9 +/- 2.1 ug/ml. furthermore, it showed inhibitory properties against -amylase and -glucosidase with ic50 values of 57.80 +/- 3.30 and 274.03 +/- 12.37 ug/ml, respectively. the molecular docking studies revealed that (e)--caryophyllene, one of the major compounds, achieved the best docking scores of -6.75, -5.61, and -7.75 for acetylcholinesterase, -amylase, and -glucosidase, respectively. thus, it is concluded that s. cumini oil should be considered as a food supplement for the elderly to enhance memory performance and for diabetic patients to control blood glucose.