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Title constituents of essential oil of origanum minutiflorum and its in vitro antioxidant, scolicidal and anticancer activities
Journal journal of king saud university - science
Year 2020
DOI https://doi.org/10.1016/j.jksus.2020.03.018
Cited By 27
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Abstract
origanum minutiflorum essential oil was evaluated for its chemical components, in vitro antioxidant, scolicidal and anticancer activities. oil was extracted and its components were identified with spectrometry and flame ionisation gas chromatography. the oil antioxidant activity was evaluated by dpph radical scavenging and -carotene/linoleic acid bleaching assay. scolicidal effect of the oil against protoscolices of hydatid cysts was evaluated at different concentrations and exposure times. also, different oil concentrations were testififed for its anticancer activities on breast cancer cell line (mcf-7), human lung cancer cell line (a-549) and human hepatocellular carcinoma cell line (hepg2) analyses of the o. minutiflorum oil identified 64 components with carvacrol being the predominant compound. the oil showed a weak free radical scavenging capacity (ic50 at 310 +/- 4.2 ug/ml) whilst it was moderately active in term of the suppression of linoleic acid oxidation (64.6%). all the tested oil concentrations, however, revealed a significant scolicidal activity on the protoscoleces of hydatid cysts. the anticancer activity of o. minutiflorum oil was found more in hepg2 cells followed by a-549 and mcf-7 cells and this was evidenced by the lc50 values. the present work strongly suggests that o. minutiflorum could serve as a potential source of scolicidal and anticancer agents.
1
Plants
29
Compounds
30
Records

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Compounds
Plants
Plant Parts
All Records
CompoundCount
alpha-terpinene2
linalool1
docosane1
heneicosane1
nerolidol1
alpha-chamigrene1
( )-caryophyllene oxide1
(+) spathulenol1
4-ethylguaiacol1
alpha-humulene1
trans-beta-caryophyllene1
carvacrol1
carvacrol methyl ether1
alpha-terpineol1
terpinen-4-ol1
borneol1
alpha-pinene1
alpha-terpinolene1
cis-sabinene hydrate1
eucalyptol1
bornylene1
para-cymene1
alpha-phellandrene1
d-3-carene1
3-octanol1
beta-myrcene1
1-octen-3-ol1
(+) beta-pinene1
camphene1
PlantFamily
Origanum minutiflorumlamiaceae
Plant PartCount
leaves30
PlantCompoundPart%
Origanum minutiflorum ( )-caryophyllene oxide leaves 0.42
Origanum minutiflorum (+) beta-pinene leaves 0.26
Origanum minutiflorum (+) spathulenol leaves 0.27
Origanum minutiflorum 1-octen-3-ol leaves 0.51
Origanum minutiflorum 3-octanol leaves 0.18
Origanum minutiflorum 4-ethylguaiacol leaves 0.55
Origanum minutiflorum alpha-chamigrene leaves 0.21
Origanum minutiflorum alpha-humulene leaves 0.1
Origanum minutiflorum alpha-phellandrene leaves 0.99
Origanum minutiflorum alpha-pinene leaves 1.33
Origanum minutiflorum alpha-terpinene leaves 1.47
Origanum minutiflorum alpha-terpinene leaves 3.94
Origanum minutiflorum alpha-terpineol leaves 0.5
Origanum minutiflorum alpha-terpinolene leaves 0.23
Origanum minutiflorum beta-myrcene leaves 1.66
Origanum minutiflorum borneol leaves 2.31
Origanum minutiflorum bornylene leaves 0.65
Origanum minutiflorum camphene leaves 1.03
Origanum minutiflorum carvacrol leaves 64.29
Origanum minutiflorum carvacrol methyl ether leaves 0.1
Origanum minutiflorum cis-sabinene hydrate leaves 1.03
Origanum minutiflorum d-3-carene leaves 0.1
Origanum minutiflorum docosane leaves 0.23
Origanum minutiflorum eucalyptol leaves 0.5
Origanum minutiflorum heneicosane leaves 0.17
Origanum minutiflorum linalool leaves 0.74
Origanum minutiflorum nerolidol leaves 0.22
Origanum minutiflorum para-cymene leaves 9.56
Origanum minutiflorum terpinen-4-ol leaves 1.14
Origanum minutiflorum trans-beta-caryophyllene leaves 2.39