the antimicrobial activity of the novel coordination polymers obtained by co-crystallizing the amino acids arginine or histidine, as both enantiopure l and racemic dl forms, with the salts cu(no3)2 and agno3 has been investigated to explore the effect of chirality in the cases of enantiopure and racemic forms. the compounds [cu.aa.(no3)2]cps and [ag.aa.no3]cps (aa = l-arg, dl-arg, l-his, dl-his) were prepared by mechanochemical, slurry, and solution methods and characterized by x-ray single-crystal and powder diffraction in the cases of the copper coordination polymers, and by powder diffraction and by solid-state nmr spectroscopy in the cases of the silver compounds. the two pairs of coordination polymers, [cu.l-arg.(no3)2.h2o]cp and [cu.dl-arg.(no3)2.h2o]cp, and [cu.l-hys.(no3)2.h2o]cp and [cu.dl-his.(no3)2.h2o]cp, have been shown to be isostructural in spite of the different chirality of the amino acid ligands. a similar structural analogy could be established for the silver complexes on the basis of ssnmr. the activity against the bacterial pathogens pseudomonas aeruginosa, escherichia coli, and staphylococcus aureus was assessed by carrying out disk diffusion assays on lysogeny agar media showing that, while there is no significant effect arising from the use of enantiopure or chiral amino acids, the coordination polymers exert an appreciable antimicrobial activity comparable, when not superior, to that of the metal salts alone.