l. and to model the interaction of some known anti-inflammatory molecules with two key enzymes involved in inflammation, 5-lypoxygenase (5-lo) and leukotriene a4 hydrolase (lta4h). gas chromatography/gas chromatography-mass spectrometry (gc/gc-ms) revealed that 92.7% of the essential oil contains 35 compounds, including oxygenated sesquiterpenes (44.2%), oxygenated monoterpenes (30.2%), monoterpene hydrocarbons (11.8%) and sesquiterpene hydrocarbons (6.5%). the major identified oxygenated terpenes are humulene oxide ii, caryophyllene oxide, khusinol, agarospirol, spathulinol and trans-pinocarveol myrtenol and -terpineol are known to exhibit anti-inflammatory activities. several complexes obtained after docking the natural terpenes with 5-lo and lta4h have shown strong hydrogen bonding interactions. the best docking energies were found with -terpineol, myrtenol and khusinol. the interaction between the natural products and amino-acid residues his367, ile673 and gln363 appears to be critical for 5-lo inhibition, while the interaction with residues glu271, his295, tyr383, tyr378, glu318, glu296 and asp375 is critical for lta4h inhibition. molecular dynamics (md) trajectories of the selected docked complexes showed stable backbone root mean square deviation (rmsd), supporting the stability of the natural product-enzyme interaction.communicated by ramaswamy h. sarma.